Neurons are capable of undergoing dynamic remodeling. During development their capacity of dynamic structural changes supports the construction of functional neuronal circuits. In the course of adult life, neurons retain the capability to undergo active structural changes. These support plasticity, including learning and the formation of lasting memories, and also counteract circuit destabilization and degeneration. Utilizing the classic genetic model organism Drosophila melanogaster, we investigate the cellular and molecular mechanisms that support neuronal resilience and dynamics in development and during the animal’s adult life. Our hypothesis is that shared molecular mechanisms control dynamics at both stages.

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