Differentiation of neuronal dendrites

Proper neuronal function is strongly dependent on its morphology. One key part of this is the correct development of dendritic arbors. In this project we utilize the dendritic arborization neurons found in the larvae of Drosophila melanogaster as a tool to investigate the dynamics of a developing dendrite and the mechanisms steering the establishment of proper dendritic morphology.

Dr. Lukas Kilo

Bachelor student:
Caterina Mongiello



Kilo, L., Stürner, T., Tavosanis, G., Ziegler, A.B., 2021. Drosophila dendritic arborisation neurons: fantastic actin dynamics and where to find them. Cells
10. https://doi.org/10.3390/cells10102777.

Stürner, T., Tatarnikova, A., Mueller, J., Schaffran, B., Cuntz, H., Zhang, Y., Nemethova, M., Bogdan, S., Small, V., Tavosanis, G., 2019. Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo. Development
146. https://doi.org/10.1242/dev.171397.

Ziegler, A.B., Thiele, C., Tenedini, F., Richard, M., Leyendecker, P., Hoermann, A., Soba, P., Tavosanis, G., 2017. Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP. Cell Rep.
21, 3346–3353. https://doi.org/10.1016/j.celrep.2017.11.069.

Nagel, J., Delandre, C., Zhang, Y., Förstner, F., Moore, A.W., Tavosanis, G., 2012. Fascin controls neuronal class-specific dendrite arbor morphology. Development
139, 2999–3009. https://doi.org/10.1242/dev.077800.