Animals can discriminate against very similar stimuli, but are also able to incorporate such stimuli into a learned group of stimuli and generalise a meaning. Different strategies have been implemented in the design of the neural circuit to achieve an optimum balance between stimuli discrimination and generalisation. Using connectomics analysis, computational modelling, and functional imaging, we investigate how the Drosophila mushroom body circuit provides the basis for this optimum balance.
Ivy Chan
ivy.chan(at)devbiol.rwth-aachen.de
Dr. Felipe Yaroslav Kalle Kossio
felipe.kalle(at)rwth-aachen.de
Publications:
Fuhrmann F, Nebeling FC, Musacchio F, Mittag M, Poll S, Müller M, Ambrad Giovannetti E, Maibach M, Schaffran B, Burnside E, Chan ICW, Lagurin AS, Reichenbach N, Kaushalya S, Fried H, Linden S, Petzold GC, Tavosanis G, Bradke F, Fuhrmann M. 2025. Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution. Communications Biology. https://www.nature.com/articles/s42003-025-08079-8
Baltruschat, L., Prisco, L., Ranft, P., Lauritzen, J.S., Fiala, A., Bock, D.D., Tavosanis, G., 2021. Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation. Cell Rep.
34, 108871. https://doi.org/10.1016/j.celrep.2021.108871.
Prisco, L., Deimel, S.H., Yeliseyeva, H., Fiala, A., Tavosanis, G., 2021. The anterior paired lateral neuron normalizes odour-evoked activity in the Drosophila mushroom body calyx. eLife
10. https://doi.org/10.7554/eLife.74172.
Christiansen, F., Zube, C., Andlauer, T.F.M., Wichmann, C., Fouquet, W., Owald, D., Mertel, S., Leiss, F., Tavosanis, G., Luna, A.J.F., Fiala, A., Sigrist, S.J., 2011. Presynapses in Kenyon cell dendrites in the mushroom body calyx of Drosophila. J. Neurosci.
31, 9696–9707. https://doi.org/10.1523/JNEUROSCI.6542-10.2011.
Kremer, M.C., Christiansen, F., Leiss, F., Paehler, M., Knapek, S., Andlauer, T.F.M., Förstner, F., Kloppenburg, P., Sigrist, S.J., Tavosanis, G., 2010. Structural long-term changes at mushroom body input synapses. Curr. Biol.
20, 1938–1944. https://doi.org/10.1016/j.cub.2010.09.060.
Leiss, F., Groh, C., Butcher, N.J., Meinertzhagen, I.A., Tavosanis, G., 2009a. Synaptic organization in the adult Drosophila mushroom body calyx. J. Comp. Neurol.
517, 808–824. https://doi.org/10.1002/cne.22184.
