Developmental assembly of neuronal circuits

Building complex functional circuits requires accurate neuronal partner matching. Several molecular key players in the process of circuit assembly have been identified through genetic screens performed in stereotypical circuits of the optic lobe and antennal lobe in Drosophila. However, circuit wiring is not fully understood in the context of non-stereotypical neuronal circuits. Hence, we are interested in understanding the mechanisms underlying developmental assembly of the non-stereotypical mushroom body calyx in Drosophila.

Funded by: FOR 2705

Ph.D. student:
Komal Patil



  1. Baltruschat, L., Prisco, L., Ranft, P., Lauritzen, J.S., Fiala, A., Bock, D.D., Tavosanis, G., 2021. Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation. Cell Rep.
    34, 108871.

  2. Marchetti, G., Tavosanis, G., 2019. Modulators of hormonal response regulate temporal fate specification in the Drosophila brain. PLoS Genet.
    15, e1008491.

  3. Marchetti, G., Tavosanis, G., 2017. Steroid hormone ecdysone signaling specifies mushroom body neuron sequential fate via chinmo. Curr. Biol.
    27, 3017-3024.e4.

  4. Christiansen, F., Zube, C., Andlauer, T.F.M., Wichmann, C., Fouquet, W., Owald, D., Mertel, S., Leiss, F., Tavosanis, G., Luna, A.J.F., Fiala, A., Sigrist, S.J., 2011. Presynapses in Kenyon cell dendrites in the mushroom body calyx of Drosophila. J. Neurosci.
    31, 9696–9707.

  5. Kremer, M.C., Christiansen, F., Leiss, F., Paehler, M., Knapek, S., Andlauer, T.F.M., Förstner, F., Kloppenburg, P., Sigrist, S.J., Tavosanis, G., 2010. Structural long-term changes at mushroom body input synapses. Curr. Biol.
    20, 1938–1944.

  6. Leiss, F., Groh, C., Butcher, N.J., Meinertzhagen, I.A., Tavosanis, G., 2009a. Synaptic organization in the adult Drosophila mushroom body calyx. J. Comp. Neurol.
    517, 808–824.